Practical aspects of inner ear gene delivery for research and clinical applications

S Lee, A Dondzillo, SP Gubbels, Y Raphael - Hearing research, 2020 - Elsevier
The application of gene therapy is widely expanding in research and continuously improving
in preparation for clinical applications. The inner ear is an attractive target for gene therapy
for treating environmental and genetic diseases in both the auditory and vestibular systems.
With the lack of spontaneous cochlear hair cell replacement, hair cell regeneration in adult
mammals is among the most important goals of gene therapy. In addition, correcting gene
defects can open up a new era for treating inner ear diseases. The relative isolation and …